专利详情

专利名称	Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth
申请号	US20060992249	专利类型	US
公开（公告）号	US8124657(B2)	公开（授权）日	2012.02.28
申请（专利权）人	中国科学院高能物理研究所	发明（设计）人	ZHAO YULIANGCHEN CHUNYINGXING GENGME
主分类号	A61K31/047	IPC主分类号	A61K31/047;C07C35/00
专利有效期	Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth 至Metallofullerols and their applications for preparation of medicine for inhibition of tumor growth	法律状态
说明书摘要	This invention provides a composition of polyhydroxylated metallofullerene compound and its application in the preparation of antitumor pharmaceutical. In one embodiment, metallofullerol comprising the formula, M@C2m(OH)x, wherein M is selected from rare earth elements such as La or Gd; m is carbon atoms of 41 or 30; x is a number of hydroxyl group of from 10 to about 50. Actually, due to the reset of the neighboring hydroxyl, the numbers of O and H in Carbon cage are different, formula are thus written as M@C2mOxHy. Comparing to the clinical anticancer drugs such as Paclitaxel, Cyclophosphamide, and Cisplatin, metallofullerol of M@C2m(OH)x or M@C2mOxHy has superior advantages of higher antitumor efficiency, low dosage, low toxicity, and better biocompatibility.