专利详情

专利名称	2-2'-Bis-thiazole derivatives as antiviral agents
申请号	EP20100000847	专利类型	EP
公开（公告）号	EP2218720(B1)	公开（授权）日	2013.01.09
申请（专利权）人	中国科学院上海药物研究所	发明（设计）人	NAN, FAJUN;ZUO, JIANPING;WANG, WENLONG;WANG, GUIFENG;CHEN, HAIJUN;HE, PEILAN
主分类号	C07D417/04	IPC主分类号	C07D417/04;A61K31/41;A61K31/42;A61K31/425;C07D403/04;C07D405/04;C07D407/04;C07D409/04;C07D413/04;C07D413/14;C07D417/14
专利有效期	2-2'-Bis-thiazole derivatives as antiviral agents 至2-2'-Bis-thiazole derivatives as antiviral agents	法律状态
说明书摘要	The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.